Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC066
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-07 10:46
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment new patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 26 individuals with a value less than 0.61 were subsequently diagnosed with PD. That is, 61.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.61 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 18, 'TN': 13, 'TP': 24, 'FP': 17}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 31, 'TN': 26, 'TP': 11, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 24, 'TN': 19, 'TP': 18, 'FP': 11}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 11.308
timePerCircleCoV 0.361438
timePerCircleSlope -0.0137848
meanError 1.94421
tremorFreq 5.76172
tremorRelPower 31.8359
tremorGyroAmpMean 0.0262866
tremorGyroAmpSlope 0.00370007
tremorGyroAmpCoV 0.334269
tremorCoordAmpMean 0.0438331
tremorCoordAmpSlope 0.00143981
tremorCoordAmpCoV 0.412578
tremorAccAmpMean 0.0935975
tremorAccAmpSlope 0.000625805
tremorAccAmpCoV 0.0852569
tremorPcRelVar 0.633523
tremorPcX 0.288114
tremorPcY 0.957596

Circle Segment 1

Duration 13.96 s, Accuracy Estimate 1.693 (lower is better)

Circle Segment 2

Duration 8.72 s, Accuracy Estimate 1.949 (lower is better)

Circle Segment 3

Duration 18.4 s, Accuracy Estimate 1.213 (lower is better)

Circle Segment 4

Duration 8.88 s, Accuracy Estimate 1.354 (lower is better)

Circle Segment 5

Duration 7.84 s, Accuracy Estimate 1.547 (lower is better)

Circle Segment 6

Duration 13.32 s, Accuracy Estimate 3.12 (lower is better)

Circle Segment 7

Duration 9.4 s, Accuracy Estimate 1.138 (lower is better)

Circle Segment 8

Duration 8.16 s, Accuracy Estimate 1.695 (lower is better)

Circle Segment 9

Duration 7.24 s, Accuracy Estimate 1.976 (lower is better)

Circle Segment 10

Duration 17.16 s, Accuracy Estimate 3.757 (lower is better)

Spiral

numSpirals 8
timePerSpiralMean 29.86
timePerSpiralCoV 0.103791
timePerSpiralSlope -0.0219756
meanError 1.58521
tremorFreq 5.85938
tremorRelPower 38.1603
tremorGyroAmpMean 0.0244882
tremorGyroAmpSlope -0.000710048
tremorGyroAmpCoV 0.355688
tremorCoordAmpMean 0.0491161
tremorCoordAmpSlope 0.00030794
tremorCoordAmpCoV 0.323012
tremorAccAmpMean 0.0596688
tremorAccAmpSlope 0.000286309
tremorAccAmpCoV 0.216651
tremorPcRelVar 0.671535
tremorPcX 0.194941
tremorPcY -0.980815

Spiral Segment 1

Duration 36.0 s, Accuracy Estimate 1.538 (lower is better)

Spiral Segment 2

Duration 32.2 s, Accuracy Estimate 1.483 (lower is better)

Spiral Segment 3

Duration 27.96 s, Accuracy Estimate 1.475 (lower is better)

Spiral Segment 4

Duration 26.96 s, Accuracy Estimate 1.58 (lower is better)

Spiral Segment 5

Duration 28.96 s, Accuracy Estimate 1.801 (lower is better)

Spiral Segment 6

Duration 28.36 s, Accuracy Estimate 1.638 (lower is better)

Spiral Segment 7

Duration 27.2 s, Accuracy Estimate 1.585 (lower is better)

Spiral Segment 8

Duration 31.24 s, Accuracy Estimate 1.582 (lower is better)

Elel

eDurationMean 0.748462
eDurationStd 0.216479
eDurationStdnorm 0.289233
eDurationMedian 0.705
eDurationQuartdelta 0.1825
eDurationQuartdeltanorm 0.258865
eDurationKurt 6.01544
eDurationTrenddiff -0.12
eDurationTrendratio 0.842105
eWidthMean 2.475
eWidthStd 0.924592
eWidthStdnorm 0.373572
eWidthMedian 2.574
eWidthQuartdelta 1.404
eWidthQuartdeltanorm 0.545455
eWidthKurt 2.11401
eWidthTrenddiff 1.053
eWidthTrendratio 1.6
eHeightMean 6.909
eHeightStd 1.69633
eHeightStdnorm 0.245525
eHeightMedian 7.02
eHeightQuartdelta 1.9305
eHeightQuartdeltanorm 0.275
eHeightKurt 9.14915
eHeightTrenddiff 0.351
eHeightTrendratio 1.05172
eAspectMean 0.35396
eAspectStd 0.0973314
eAspectStdnorm 0.274978
eAspectMedian 0.348485
eAspectQuartdelta 0.136312
eAspectQuartdeltanorm 0.391155
eAspectKurt 2.35955
eAspectTrenddiff 0.117855
eAspectTrendratio 1.4021
eSlantMean -0.0538678
eSlantStd 0.132185
eSlantStdnorm -2.45387
eSlantMedian -0.0410959
eSlantQuartdelta 0.169763
eSlantQuartdeltanorm -4.1309
eSlantKurt 2.81078
eSlantTrenddiff 0.0834353
eRtopMean 0.722071
eRtopStd 0.1166
eRtopStdnorm 0.161479
eRtopMedian 0.75
eRtopQuartdelta 0.169779
eRtopQuartdeltanorm 0.226373
eRtopKurt 2.95003
eRtopTrenddiff -0.0192308
eRbotMean 0.961854
eRbotStd 0.457798
eRbotStdnorm 0.475954
eRbotMedian 0.875
eRbotQuartdelta 0.488629
eRbotQuartdeltanorm 0.558433
eRbotKurt 7.43186
eRbotTrenddiff -0.275
eRrightMean 0.883576
eRrightStd 0.0650617
eRrightStdnorm 0.0736345
eRrightMedian 0.880597
eRrightQuartdelta 0.0755259
eRrightQuartdeltanorm 0.0857667
eRrightKurt 3.04437
eRrightTrenddiff -0.0133424
eRleftMean 0.436171
eRleftStd 0.103034
eRleftStdnorm 0.236223
eRleftMedian 0.4375
eRleftQuartdelta 0.155154
eRleftQuartdeltanorm 0.354638
eRleftKurt 2.29645
eRleftTrenddiff -0.0346084
lDurationMean 1.07313
lDurationStd 0.374889
lDurationStdnorm 0.349343
lDurationMedian 0.9575
lDurationQuartdelta 0.4625
lDurationQuartdeltanorm 0.483029
lDurationKurt 3.03278
lDurationTrenddiff -0.25
lDurationTrendratio 0.772727
lWidthMean 2.6208
lWidthStd 0.7669
lWidthStdnorm 0.292621
lWidthMedian 2.574
lWidthQuartdelta 0.936
lWidthQuartdeltanorm 0.363636
lWidthKurt 3.22704
lWidthTrenddiff -0.117
lWidthTrendratio 0.955556
lHeightMean 14.4612
lHeightStd 2.34686
lHeightStdnorm 0.162287
lHeightMedian 14.3325
lHeightQuartdelta 3.9195
lHeightQuartdeltanorm 0.273469
lHeightKurt 2.1019
lHeightTrenddiff -2.1645
lHeightTrendratio 0.857143
lAspectMean 0.181924
lAspectStd 0.0488812
lAspectStdnorm 0.268691
lAspectMedian 0.168367
lAspectQuartdelta 0.0556191
lAspectQuartdeltanorm 0.330344
lAspectKurt 4.47594
lAspectTrenddiff 0.00157562
lAspectTrendratio 1.00943
lSlantMean 0.005506
lSlantStd 0.0643293
lSlantStdnorm 11.6835
lSlantMedian 0.0136856
lSlantQuartdelta 0.0693914
lSlantQuartdeltanorm 5.07038
lSlantKurt 3.68686
lSlantTrenddiff 0.0110082
lRtopMean 0.819395
lRtopStd 0.122632
lRtopStdnorm 0.149661
lRtopMedian 0.848077
lRtopQuartdelta 0.134943
lRtopQuartdeltanorm 0.159117
lRtopKurt 5.7691
lRtopTrenddiff 0.0527945
lRbotMean 0.836556
lRbotStd 0.338283
lRbotStdnorm 0.404376
lRbotMedian 0.794737
lRbotQuartdelta 0.330173
lRbotQuartdeltanorm 0.41545
lRbotKurt 3.29218
lRbotTrenddiff 0.0355662
lRrightMean 0.910153
lRrightStd 0.0834497
lRrightStdnorm 0.0916875
lRrightMedian 0.926378
lRrightQuartdelta 0.0630541
lRrightQuartdeltanorm 0.0680652
lRrightKurt 8.31792
lRrightTrenddiff -0.0127898
lRleftMean 0.324331
lRleftStd 0.133682
lRleftStdnorm 0.412178
lRleftMedian 0.286421
lRleftQuartdelta 0.190671
lRleftQuartdeltanorm 0.665699
lRleftKurt 4.02906
lRleftTrenddiff -0.0251065

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

FITTS Short Modified

meanTouchScore 0.916254
sumTouchScores 15.5763
meanMovementTime 1.09781
numTouches 17
undershootPercentage 0
overshootPercentage 23.5294

FITTS Long Modified

meanTouchScore 0.798274
sumTouchScores 10.3776
meanMovementTime 1.46792
numTouches 13
undershootPercentage 7.69231
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 26.528
timePerZigzagCoV 0.201674
timePerZigzagSlope -0.111882
meanError 2.51454
tremorFreq 5.56641
tremorRelPower 40.6401
tremorGyroAmpMean 0.0355728
tremorGyroAmpSlope 0.00327721
tremorGyroAmpCoV 0.349792
tremorCoordAmpMean 0.0615566
tremorCoordAmpSlope 0.00275077
tremorCoordAmpCoV 0.338045
tremorAccAmpMean 0.0683493
tremorAccAmpSlope 0.0021427
tremorAccAmpCoV 0.256013
tremorPcRelVar 0.752347
tremorPcX 0.0385779
tremorPcY -0.999256

ZigZag Segment 1

Duration 35.16 s, Accuracy Estimate 1.971 (lower is better)

ZigZag Segment 2

Duration 27.16 s, Accuracy Estimate 2.471 (lower is better)

ZigZag Segment 3

Duration 23.56 s, Accuracy Estimate 2.76 (lower is better)

ZigZag Segment 4

Duration 25.72 s, Accuracy Estimate 2.58 (lower is better)

ZigZag Segment 5

Duration 21.04 s, Accuracy Estimate 2.79 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 16.912
timePerZigzagCoV 0.172102
timePerZigzagSlope -0.104778
zigzagHeightMean 68.0659
zigzagHeightCoV 0.09868
zigzagHeightSlope -0.0433393
meanError 0.0360145
tremorFreq 6.15234
tremorRelPower 36.0211
tremorGyroAmpMean 0.033672
tremorGyroAmpSlope 0.00656424
tremorGyroAmpCoV 0.393374
tremorCoordAmpMean 0.0768591
tremorCoordAmpSlope 0.00643332
tremorCoordAmpCoV 0.28829
tremorAccAmpMean 0.0894777
tremorAccAmpSlope 0.00319622
tremorAccAmpCoV 0.198884
tremorPcRelVar 0.835617
tremorPcX 0.12065
tremorPcY -0.992695

ZigZag Offset Segment 1

Duration 21.24 s, Accuracy Estimate 0.048 (lower is better)

ZigZag Offset Segment 2

Duration 18.24 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 3

Duration 15.76 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 4

Duration 15.64 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 5

Duration 13.68 s, Accuracy Estimate 0.047 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.73}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.61}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.3098306651587319}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9235860087150005}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8356918293692512}